Description
Full-length recombinant human MASTL was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number for MASTL is NM_001172303.
Microtubule associated serine/threonine kinase-like (MASTL) belongs to the MAST family, AGC Ser/Thr protein kinase group. MASTL promotes mitotic progression and cell cycle reentry after DNA damage. Loss of MASTL leads to defects in chromosome condensation, separation, and other aspects of mitotic progression, which is primarily mediated by inhibiting PP2A/B55delta. Overexpression of MASTL is correlated with cancer progression, poor patient survival, and tumor recurrence in various cancers